Drug Interactions With the Lidocaine Patch

Taking certain medications in combination with the lidocaine patch may result in negative interactions. For example, taking this drug with certain arrhythmia medications or local anesthetics may cause problems with the lidocaine patch. Drug interactions may be avoided if you inform your healthcare provider of all medications you are using, including nonprescription medicines.

An Overview of Lidocaine Patch Interactions

Even though the lidocaine patch (Lidoderm® patch) is applied to the skin, it can potentially interact with several other medications (as some of the medication is absorbed into the bloodstream). Some of these medicines that may lead to drug interactions with the lidocaine patch include:
 
  • Class I arrhythmia medications, such as:
     
    • Disopyramide (Norpace®, Norpace® CR)
    • Flecainide (Tambocor™)
    • Mexiletine
    • Phenytoin (Dilantin®, Phenytek®)
    • Procainamide
    • Propafenone (Rythmol®, Rythmol® SR)
    • Quinidine
 
  • Local anesthetics (any anesthetics applied or injected in order to achieve pain relief or numbness in a specific area), such as those used in dental procedures.
     

Drug Interactions With the Lidocaine Patch Explained

The following sections offer more details on combining the lidocaine patch with any of the drugs listed above.
 
 
Class I Antiarrhythmics
In addition to its use as an anesthetic, lidocaine (the active ingredient in the lidocaine patch) is also an arrhythmia medication. Caution should be used if lidocaine is combined with other similar arrhythmia medications (especially Class I arrhythmia medications).
Drug Interactions With the Lidocaine Patch Article Continues on Next Page >
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
Other Articles in This eMedTV Presentation
Referring Pages Articles