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Valtrex and DepressionSeveral side effects are possible with Valtrex, and depression is one of them. Up to 7 percent of people taking Valtrex for genital herpes suppression and 1 percent of people taking it for genital herpes treatment reported this side effect. Because of the likely link between Valtrex and depression, it is important to talk to your healthcare provider if you experience feelings of guilt, worthlessness, and hopelessness or if something just does not seem "right."
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
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